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Ionic Liquids as New Solvents for Improved Separation of Medical Isotopes

Oak Ridge National Laboratory

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PDF Document Publication11-G00234_ID2580 (2).pdf (942 KB)

Technology Marketing SummaryA series of ionic liquids (ILs) have recently been applied as new solvents for potentially effective separation of different medical isotopes at ORNL. The uniqueness of these ILs includes excellent separation factors using neat ILs without any dissolved extractant ligand.DescriptionThe daughters of thorium-229 (actinium-225 and bismuth-213) and other alphaemitting
radioisotopes are rapidly becoming of great interest for short-range and
site-specific therapy of cancers and micrometastic disease. In many of the current
medical isotope generator systems, the production process uses an organic
exchange resin. Radiolytic breakdown of these generators limits their size to a few
millicuries and their useful lifetime to a few days.
Benefits•Clean separation; removes daughters with one step
•Less isotope degradation
•Less risk for isotope generation
Applications and Industries•Treatment of various forms of cancer
•Development of a new medical isotope generator
•Could possibly be used for Mo-99/Tcm-99 separation
More InformationApplication in preparation: Huimin Luo, Energy and Transportation Science Division, Oak Ridge National LaboratoryTechnology Status
Technology IDDevelopment StageAvailabilityPublishedLast Updated
UT-B ID 201102580ProposedAvailable11/21/201110/25/2011

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To: David L. Sims<>