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Multifocal Multiphoton Laser-Scanning Structured Illumination Microscopy with Whole-Field Detection

Colorado School of Mines

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Technology Marketing SummaryThis invention describes a multiphoton imaging process in conjunction with whole field detection which gives it the ability to penetrate deeper into highly scattering media. 
DescriptionThis system may be used for imaging beyond the diffraction limit in the highly scattering media and in a number of modalities, such as two-photon excitation fluorescence (TPEF), harmonic generation (HG), and coherent anti-Stokes Raman scattering (CARS).  The system is also, applicable for any imaging modality, whether linear or nonlinear in excitation.Benefits
  • Deep penetration into biological and other highly scattering media
  • Ability to image beyond the diffraction limit and in many modalities
  • Ability to create multiple foci for simultaneous acquisition of structured illumination microscopy data
Applications and Industries
  • Investigation of biological tissues
  • Chemical analysis
  • Resolution on the molecular level
More InformationProvisional Patent filed May 31, 2011Technology Status
Development StageAvailabilityPublishedLast Updated
DevelopmentAvailable - We are seeking an exclusive or non-exclusive licensee for marketing, manufacturing, and sale of this technology.06/14/201106/14/2011

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To: William Vaughan<>