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Directed Spontaneous Assembly of Membrane Protein with Amphiphilic Block Copolymers

Colorado School of Mines

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Technology Marketing SummaryThis invention describes a method for using membrane proteins (MPs) in synthetic systems for biosensor design, high-throughput drug-screening, catalysis or energy harvesting.
DescriptionCurrent efforts in the art face a challenge that practical applications involving liposomes have been continually hindered by their lack of stability.  This invention used polymersome membranes as structural materials to support MP functions in lieu of biologically-derived lipid bilayers.  A series of amphiphilic block copolymers with systematically varied membrane-forming blocks were designed.  Investigation of the design found that charge-interaction directed assembly paradigm is applicable to the polymersome system to induce the formation of 3-D hierarchically ordered proteopolymersome membranes spontaneously, even when the membrane block is in entangled or glassy states.Benefits
  • Doesn’t use unstable liposomes
  • Spontaneously ordered
  • Membrane could be in entangled or glassy states
Applications and Industries
  • Biosensor design
  • High-throughput drug-screening
  • Catalysis  
More Information

Provisional Patent filed May 31, 2011

Technology Status
Development StageAvailabilityPublishedLast Updated
DevelopmentAvailable - We are seeking an exclusive or non-exclusive licensee for marketing, manufacturing, and sale of this technology.06/14/201106/14/2011

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To: William Vaughan<>