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Mechanochemical Preparation of Phosphonium Salts and Phosphorus Ylides

Ames Laboratory

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Technology Marketing SummaryResearchers at Iowa State University and Ames Laboratory have developed a unique, solvent-free mechanochemical preparation method to prepare phosphonium salts and phosphorous ylides. The phosphorous ylides are then utilized in carrying out the solvent-free synthesis of desired organic compounds employing the Wittig-Horner reaction.DescriptionThis is a unique, solvent-free mechanochemical preparation method to prepare phosphonium salts and phosphorous ylides. The phosphorous ylides are then utilized in carrying out the solvent-free synthesis of desired organic compounds employing the Wittig-Horner reaction.BenefitsThe advantages include 1) Complete elimination of solvents from the reaction course, which would reduce the cost of the final product, and substantially reduce the hazardous and environmentally harmful chemical pollution and waste caused from the organic solvents (e.g. toluene, benzene, or hexane). 2) Extremely high selectivity of the chemical, and therefore, the relative absence of side products. 3) High yields of products (90% yields experienced). 4) Low processing temperatures close to ambient (no heat required). 5) Process should be scalable with simple and commercially available equipment.Applications and Industries* Simple, mechanochemical process for production of phosphonium salts and phosphorous ylides * Replaces traditional organic synthesis
* Suitable for chemical and pharmaceutical uses
Technology Status
Technology IDDevelopment StageAvailabilityPublishedLast Updated
2847DevelopmentAvailable12/07/201012/16/2010

Contact AMES About This Technology

To: Stacy Joiner<joiner@ameslab.gov>