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Plant rhamnogalacturonan II complexation of heavy metal cations

United States Patent

March 2, 1999
View the Complete Patent at the US Patent & Trademark Office
The present invention provides rhamnogalacturonan-II (RG-II) and relates to its ability to complex specific multivalent heavy metal cations. In the presence of boric acid, RG-II monomers form dimers that are cross-linked by a borate ester. The yield of such borate ester cross-linked dimers of RG-II is enhanced in the presence of specific heavy metal cations. The present invention further relates to the utility of RG-II in assays for the detection of specific heavy metal contamination; as a reagent useful in the removal of specific heavy metal cations contaminating foods and liquids, for example, fish, wines, etc.; as a pharmaceutical composition useful as an antidote in specific heavy metal cation poisoning; as a treatment for the detoxification of specific heavy metal cations from blood and/or tissues; and in a method of remediation of waters and soils contaminated with specific heavy metal cations.
O'Neill; Malcolm A. (Winterville, GA), Pellerin; Patrice J. M. (Montpellier, FR), Warrenfeltz; Dennis (Athens, GA), Vidal; Stephane (Combaillaux, FR), Darvill; Alan G. (Athens, GA), Albersheim; Peter (Athens, GA)
University of Georgia Research Foundation, Inc. (Athens, GA), Institute National de la Recherche Agronomique (Paris, FR)
08/ 755,058
November 22, 1996
ACKNOWLEDGEMENT OF GOVERNMENT FUNDING The invention was partially made with Government support under Grant DE-FG05-93ER20097 and Grant DE-FG05-93ER20115, awarded by the U.S. Department of Energy. The United States Government has certain rights in this invention.