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Y chromosome specific nucleic acid probe and method for determining the Y chromosome in situ

United States Patent

*** EXPIRED ***
November 24, 1998
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A method for producing a Y chromosome specific probe selected from highly repeating sequences on that chromosome is described. There is little or no nonspecific binding to autosomal and X chromosomes, and a very large signal is provided. Inventive primers allowing the use of PCR for both sample amplification and probe production are described, as is their use in producing large DNA chromosome painting sequences.
Gray; Joe W. (Livermore, CA), Weier; Heinz-Ulrich (Tracy, CA)
The Regents of the University of California (Alameda, CA)
07/ 594,921
October 10, 1990
This application is related to a United States patent application Ser. No. 07/954,922 entitled "PCR Method of Diagnosis of Fetal Gender from Maternal Blood" filed simultaneously with the present application. The United States Government has rights in this invention pursuant to Contract No. W-7405-ENG-48 between the United States Department of Energy and the University of California for the operation of Lawrence Livermore National Laboratory.