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Method for loading lipsomes with ionizable phosphorylated hydrophobic compounds, pharmaceutical preparations and a method for administering the preparations

United States Patent

*** EXPIRED ***
October 27, 1998
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
A method of entrapping ionizable compounds, preferably phosphorylated hydrophobic compounds, into liposomes having transmembrane gradients is disclosed. The procedures involve forming liposomes in an acidic medium or a basic medium, adding to the acidic medium a cationic compound or to the basic medium an anionic compound and then adding a base to the cationic-containing medium or an acid to the anionic-containing medium, thereby inducing the ionizable compound into the liposomes' internal aqueous phase. The compound-entrapped liposomes prepared in accordance with the disclosed methods may be used as pharmaceutical preparations. Methods of administering such pharmaceutical preparations are also disclosed.
Mehlhorn; Rolf Joachim (Richmond, CA)
The Reagents of the University of California (Oakland, CA)
08/ 791,557
January 31, 1997
ACKNOWLEDGEMENT OF GOVERNMENT SUPPORT This invention was made with Government support under Grant No. DE-AC03-76SF00098, awarded by the Department of Energy. The Government has certain rights in this invention