Skip to Content
Find More Like This
Return to Search

Amino acid analogs for tumor imaging

United States Patent

*** EXPIRED ***
5,808,146
September 15, 1998
View the Complete Patent at the US Patent & Trademark Office
The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of 1-amino-cycloalkyl-1-carboxylic acids, namely, their rapid uptake and prolonged retention in tumors with the properties of halogen substituents, including certain useful halogen isotopes including fluorine-18, iodine-123, iodine-125, iodine-131, bromine-75, bromine-76, bromine-77 and bromine-82. In one aspect, the invention features amino acid compounds that have a high specificity for target sites when administered to a subject in vivo. Preferred amino acid compounds show a target to non-target ratio of at least 5:1, are stable in vivo and substantially localized to target within 1 hour after administration. An especially preferred amino acid compound is [.sup.18 F]-1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC). In another aspect, the invention features pharmaceutical compositions comprised of an .alpha.-amino acid moiety attached to either a four, five, or a six member carbon-chain ring. In addition, the invention features analogs of .alpha.-aminoisobutyric acid.
Goodman; Mark M. (Atlanta, GA), Shoup; Timothy (Decatur, GA)
Emory University (Atlanta, GA)
08/ 554,906
November 9, 1995
The U.S. Government has certain rights in this invention, based upon partial support provided by Department of Energy Grant No. DE-FG05-93ER61737.