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Rigid bifunctional chelating agents

United States Patent

*** EXPIRED ***
July 21, 1998
View the Complete Patent at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
Bicyclo[2.2.2] octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo[2.2.1] heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.
Sweet; Mark P. (Coram, NY), Mease; Ronnie C. (Fairfax, VA), Srivastava; Suresh C. (Setauket, NY)
Brookhaven Science Associates LLC (Upton, NY)
08/ 506,889
July 26, 1995
This invention was made with Government support under contract number DE-AC02-76CH00016, between the U.S. Department of Energy and Associated Universities, Inc. The Government has certain rights in the invention.