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Brain-specific enhancers for cell-based therapy

United States Patent

April 24, 2018
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Herein are described a set of novel specific human enhancers for specific forebrain cell types used to study and select for human neural progenitor cells. This approach enables the ability to generate interneurons from human ES, iPS and iN cells, making them available for human transplantation and for molecular/cellular analyzes. These approaches are also directly applicable to generating other neuronal cell types, such as cortical and striatal projection neurons, which have implications for many human diseases.
Visel; Axel (El Cerrito, CA), Rubenstein; John L. R. (San Francisco, CA), Chen; Ying-Jiun (Jasmine), (South San Francisco, CA), Pennacchio; Len A. (Sebastopol, CA), Vogt; Daniel (Burlingame, CA), Nicholas; Cory (San Francisco, CA), Kriegstein; Arnold (Mill Valley, CA)
The Regents of the University of California (Oakland, CA)
14/ 512,306
October 10, 2014
STATEMENT OF GOVERNMENTAL SUPPORT This work was supported Grant Nos. HG003988 awarded by the National Human Genome Research Institute, Grant Nos. MH081880 and MH049428 awarded by the NIH-NIMH, Grant Nos. NS062859A and NS071785 awarded by the NIH-NINDS, by Grant Nos. RB2-01602 and RC1-00346-1 awarded by the California Institute for Regenerative Medicine, and by Contract DE-AC02-05CH11231 awarded by the Department of Energy. The government has certain rights in the invention.