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Variants of cellobiohydrolases

United States Patent

April 10, 2018
View the Complete Patent at the US Patent & Trademark Office
Disclosed are a number of homologs and variants of Hypocrea jecorina Ce17A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.
Bott; Richard R. (Burlingame, CA), Foukaraki; Maria (Rotterdam, NL), Hommes; Ronaldus Wilhelmus (Haarlem, NL), Kaper; Thijs (Half Moon Bay, CA), Kelemen; Bradley R. (Menlo Park, CA), Kralj; Slavko (Oegstgeest, NL), Nikolaev; Igor (Noordwijk, NL), Sandgren; Mats (Uppsala, SE), Van Lieshout; Johannes Franciscus Thomas (Utrecht, NL), Van Stigt Thans; Sander (Zevenbergen, NL)
14/ 650,285
December 10, 2013
GOVERNMENT RIGHTS This invention was made with government support under grant number DE-FC36-08GO18078 awarded by the U.S. Department of Energy. The government has certain rights in this invention.