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Innovative nanopore sequencing technology including a self-assembled porous membrane

United States Patent

March 27, 2018
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Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), .about.1-nm aperture "tortuous" nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.
Brueck; Steven R. J. (Albuquerque, NM), Edwards; Jeremy Scott (Albuquerque, NM), Neumann; Alexander (Albuquerque, NM), Kuznetsova; Yuliya (Albuquerque, NM), Mendoza; Edgar A. (Redondo Beach, CA), Brinker; C. Jeffrey (Albuquerque, NM)
STC.UNM (Albuquerque, NM)
14/ 555,453
November 26, 2014
GOVERNMENT RIGHTS This invention was made with government support under Grant Nos. W911NF-08-1-0214 and W911NF-11-00080 awarded by the Army Research Office (ARO) and Grant Nos. DE-FG02-02ER15368 and DE-AC04-94AL85000 awarded by the Department of Energy (DOE). The government has certain rights in the invention.