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Enhanced itaconic acid production in Aspergillus with increased LaeA expression

United States Patent

March 6, 2018
View the Complete Patent at the US Patent & Trademark Office
Pacific Northwest National Laboratory - Visit the Technology Commercialization Program Website
Fungi, such as Aspergillus niger, having a dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase (Alg3) gene genetic inactivation, increased expression of a loss of aflR expression A (LaeA), or both, are described. In some examples, such mutants have several phenotypes, including an increased production of citric acid relative to the parental strain. Methods of using the disclosed fungi to make citric acid are also described, as are compositions and kits including the disclosed fungi. Further described are Aspergillus terreus fungi overexpressing the LaeA gene and the use of such fungi for the production of itaconic acid.
Dai; Ziyu (Richland, WA), Baker; Scott E. (Richland, WA)
Battelle Memorial Institute (Richland, WA)
14/ 928,511
October 30, 2015
ACKNOWLEDGMENT OF GOVERNMENT SUPPORT This invention was made with government support under contract number DE-AC05-76RL01830 awarded by the U.S. Department of Energy. The government has certain rights in the invention.