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Quantitative detection of pathogens in centrifugal microfluidic disks

United States Patent

February 27, 2018
View the Complete Patent at the US Patent & Trademark Office
Sandia National Laboratories - Visit the Intellectual Property Management and Licensing Website
A system and methods for detection of a nucleic acid including forming a plurality of nucleic acid detection complexes are described, each of the complexes including a nucleic acid analyte, a detection agent and a functionalized probe. The method further including binding the nucleic acid detection complexes to a plurality of functionalized particles in a fluid sample and separating the functionalized particles having the nucleic acid detection complexes bound thereto from the fluid sample using a density media. The nucleic acid analyte is detected by detecting the detection agent.
Koh; Chung-Yan (Dublin, CA), Schaff; Ulrich Y. (Livermore, CA), Sommer; Gregory Jon (Livermore, CA)
National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)
13/ 941,186
July 12, 2013
GOVERNMENT RIGHTS This invention was made with Government support under Contract No. DE-AC04-94AL85000 awarded by the U.S. Department of Energy. The Government has certain rights in the invention.