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Methods of hydrolyzing a cellulose using halophilic, thermostable and ionic liquids tolerant cellulases

United States Patent

January 9, 2018
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides for an isolated or recombinant polypeptide comprising an amino acid sequence having at least 70% identity with the amino acid sequence of a Halorhabdus utahensis cellulase, such as Hu-CBH1, wherein said amino acid sequence has a halophilic thermostable and/or thermophilic cellobiohydrolase (CBH) activity. In some embodiments, the polypeptide has a CBH activity that is resistant to up to about 20% of ionic liquids. The present invention also provides for compositions comprising and methods using the isolated or recombinant polypeptide.
Zhang; Tao (San Diego, FL), Datta; Supratim (Berkeley, CA), Simmons; Blake A. (San Francisco, CA), Rubin; Edward M. (Berkeley, CA)
The Regents of the University of California (Oakland, CA), Sandia Corporation (Albuquerque, NM)
15/ 164,813
May 25, 2016
STATEMENT OF GOVERNMENTAL SUPPORT The invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy. The government has certain rights in the invention.