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Methods and compositions for controlling gene expression by RNA processing

United States Patent

August 29, 2017
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present disclosure provides nucleic acids encoding an RNA recognition sequence positioned proximal to an insertion site for the insertion of a sequence of interest; and host cells genetically modified with the nucleic acids. The present disclosure also provides methods of modifying the activity of a target RNA, and kits and compositions for carrying out the methods.
Doudna; Jennifer A. (Berkeley, CA), Qi; Lei S. (El Cerrito, CA), Haurwitz; Rachel E. (Kensington, CA), Arkin; Adam P. (San Francisco, CA)
The Regents of the University of California (Oakland, CA)
14/ 248,980
April 9, 2014
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH This invention was made with government support under Grant Nos. EEC-0540879 and MCB-0950971 awarded by the National Science Foundation, and Grant No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy. The government has certain rights in the invention.