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Positron emission tomography probe to monitor selected sugar metabolism in vivo

United States Patent

March 14, 2017
View the Complete Patent at the US Patent & Trademark Office
The invention disclosed herein discloses selected ribose isomers that are useful as PET probes (e.g. [18F]-2-fluoro-2-deoxy-arabinose). These PET probes are useful, for example, in methods designed to monitor physiological processes including ribose metabolism and/or to selectively observe certain tissue/organs in vivo. The invention disclosed herein further provides methods for making and using such probes.
Witte; Owen (Sherman Oaks, CA), Clark; Peter M. (Los Angeles, CA), Castillo; Blanca Graciela Flores (Van Nuys, CA), Jung; Michael E. (Los Angeles, CA), Evdokimov; Nikolai M. (Los Angeles, CA)
The Regents of the University of California (Oakland, CA)
14/ 399,701
May 9, 2013
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT This invention was made with Government support under Grant Number DE-SC0001249, awarded by the U.S. Department of Energy and under Grant Number CA098010, awarded by the National Institutes of Health. The Government has certain rights in the invention.