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Modular radiochemistry synthesis system

United States Patent

November 1, 2016
View the Complete Patent at the US Patent & Trademark Office
A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.
Satyamurthy; Nagichettiar (Los Angeles, CA), Barrio; Jorge R. (Agoura Hills, CA), Amarasekera; Bernard (Winnetka, CA), Van Dam; R. Michael (Los Angeles, CA), Olma; Sebastian (Muenster, DE), Williams; Dirk (Northridge, CA), Eddings; Mark (San Pedro, CA), Shen; Clifton Kwang-Fu (Westlake Village, CA)
14/ 941,164
November 13, 2015
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT This invention was made with Government support under Grant No. DE-FG02-06ER64249, awarded by the U.S. Department of Energy, and Grant No. CA086306, awarded by the National Institute of Health. The Government has certain rights in the invention.