Skip to Content
Find More Like This
Return to Search

Host cells and methods for producing 1-deoxyxylulose 5-phosphate (DXP) and/or a DXP derived compound

United States Patent

July 5, 2016
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides for a genetically modified host cell capable of producing 1-deoxyxylulose 5-phosphate or 1-deoxy-D-xylulose 5-phosphate (DXP) (12), and optionally one or more DXP derived compounds, comprising: (a) a mutant RibB, or functional variant thereof, capable of catalyzing xylulose 5-phosphate and/or ribulose 5-phosphate to DXP, or (b) a YajO, or functional variant thereof, and a XylB, or functional variant thereof.
Kirby; James (Berkeley, AZ), Fortman; Jeffrey L. (San Francisco, CA), Nishimoto; Minobu (El Cerrito, CA), Keasling; Jay D. (Berkeley, CA)
The Regents of the University of California (Oakland, CA)
13/ 587,826
August 16, 2012
STATEMENT OF GOVERNMENTAL SUPPORT The invention described and claimed herein was made utilizing funds supplied by the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. The government has certain rights in this invention.