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Thermostable cellulases, and mutants thereof, capable of hydrolyzing cellulose in ionic liquid

United States Patent

April 26, 2016
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides for a composition comprising an ionic liquid and a thermostable cellulose, and a method of hydrolyzing a cellulose, comprising: (a) providing a composition comprising a solution comprising an ionic liquid and a cellulose, and (b) introducing a thermostable cellulase to the solution, such that the cellulose is hydrolyzed by the cellulase. The present invention also provides for a Thermatoga maritima thermostable cellulase mutant with increased cellulase activity.
Sapra; Rajat (Pennington, NJ), Datta; Supratim (Berkeley, CA), Chen; Zhiwei (El Cerrito, CA), Holmes; Bradley M. (Oakland, CA), Simmons; Blake A. (San Francisco, CA), Blanch; Harvey W. (San Francisco, CA)
The Regents of the University of California (Oakland, CA), Sandia Corporation (Livermore, CA)
13/ 265,786
April 23, 2010
STATEMENT OF GOVERNMENTAL SUPPORT The invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy. The government has certain rights in the invention.