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Preparation of 4-amino-2,4-dioxobutanoic acid

United States Patent

June 2, 2015
View the Complete Patent at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
A process for synthesizing 4-amino-2,4-dioxobutanoic acid involves reacting diethyl oxalate with sodium ethoxide in ethanol to form a reaction mixture, and afterward adding ethyl cyanoacetate to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product of the formula diethyl-2-cyano-3-hydroxy-butenedioate, and then isolating the diethyl-2-cyano-3-hydroxybutenedioate, and afterward reacting the diethyl-2-cyano-3-hydroxy-butenedioate with aqueous sodium hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoic acid.
Unkefer; Pat J. (Los Alamos, NM), Martinez; Rodolfo A. (Santa Fe, NM), Glass; David R. (Las Vegas, NM)
Los Alamos National Security, LLC (Los Alamos, NM), New Mexico Highlands University (Las Vegas, NM)
13/ 828,905
March 14, 2013
STATEMENT REGARDING FEDERAL RIGHTS This invention was made with government support under Contract No. DE-AC52-06NA25396 awarded by the U.S. Department of Energy. The government has certain rights in the invention.