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Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production

United States Patent

November 18, 2014
View the Complete Patent at the US Patent & Trademark Office
The present disclosure provides novel beta-alanine/alpha ketoglutarate aminotransferase nucleic acid and protein sequences having increased biological activity. Also provided are cells containing such enzymes, as well as methods of their use, for example to produce malonyl semialdehyde and downstream products thereof, such as 3-hydroxypropionic acid and derivatives thereof.
Jessen; Holly Jean (Belgrade, MT), Liao; Hans H. (Eden Prairie, MN), Gort; Steven John (Apple Valley, MN), Selifonova; Olga V. (Plymouth, MN)
Cargill, Incorporated (Wayzata, MN)
13/ 230,217
September 12, 2011
ACKNOWLEDGEMENT OF GOVERNMENT SUPPORT This invention was made with United States Government support under contract GO 13144 awarded by the Department of Energy. The United States Government has certain rights in this invention.