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Using phylogenetic probes for quantification of stable isotope labeling and microbial community analysis

United States Patent

December 9, 2014
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Herein is described methods for a high-sensitivity means to measure the incorporation of stable isotope labeled substrates into RNA following stable isotope probing experiments (SIP). RNA is hybridized to a set of probes such as phylogenetic microarrays and isotope incorporation is quantified such as by secondary ion mass spectrometer imaging (NanoSIMS).
Brodie; Eoin L. (Piedmont, CA), DeSantis; Todd Z. (Livermore, CA), Karaoz; Ulas (Berkeley, CA), Andersen; Gary L. (Berkeley, CA)
The Regents of the University of California (Oakland, CA)
13/ 023,538
February 8, 2011
STATEMENT OF GOVERNMENTAL SUPPORT This invention was made in part by the US DOE Office of Biological and Environmental Research Genomic Sciences research program and the LLNL Laboratory Directed Research and Development (LDRD) program with government support under Contract No. DE-AC02-05CH11231 and under Contract DE-AC52-07NA27344 awarded by the U.S. Department of Energy. The government has certain rights in the invention.