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Photoreactive synthetic regulator of protein function and methods of use thereof

United States Patent

March 31, 2015
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.
Trauner; Dirk (Munich, DE), Isacoff; Ehud Y. (Berkeley, CA), Kramer; Richard H. (Oakland, CA), Banghart; Matthew R. (Oakland, CA), Fortin; Doris L. (Ottawa, AA), Mourot; Alexandre (Berkeley, CA)
The Regents of the University of California (Oakland, CA)
13/ 059,052
October 29, 2009
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH This invention was made with government support under Grant No. 1PN2-EY018241 awarded by the National Institutes of Health, Grant No. CHE 0724212 awarded by the National Science Foundation, and Contract DE-AC02-05CH11231 awarded by the U.S. Department of Energy. The government has certain rights in the invention.