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Saccharide antifreeze compositions

United States Patent

December 10, 2013
View the Complete Patent at the US Patent & Trademark Office
The invention provides an antifreeze glycolipid compounds and composition comprising a polysaccharide moiety of Formula I: ##STR00001## wherein D-Manp represents a D-mannopyranose moiety, D-Xylp represents a D-xylopyranose moiety, and n is about 5 to about 70; and one or more lipid moieties covalently linked to the polysaccharide moiety of Formula I or electrostatically associated with the polysaccharide moiety of Formula I. The antifreeze glycolipid compounds and compositions can be used for a variety of industrial, agricultural, medical, and cosmetic applications where recrystallization-inhibition, cyroprotection, or cryopreservation is desired. The antifreeze glycolipid compounds or compositions can be used as, for example, as cryoprotectants for tissue preservation and transplantation, improving the texture of processed frozen food and frozen meats, frostbite protection, crop protection, and green alternatives for land vehicle antifreeze and aircraft de-icing.
Walters; Kent (Notre Dame, IN), Duman; John G. (Niles, MI), Serianni; Anthony S. (Notre Dame, IN)
University of Notre Dame Du Lac (Norte Dame, IN)
13/ 135,065
June 23, 2011
GOVERNMENT SUPPORT This invention was made with government support under Grant Nos. OPP-0117104 and IOS-0618342 awarded by the National Science Foundation and Grant No. DE-FG09-93ER-20097 awarded by the Department of Energy. The United States Government has certain rights in the invention.