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Methylocystis strain SB2 materials and methods

United States Patent

January 14, 2014
View the Complete Patent at the US Patent & Trademark Office
The present disclosures provides isolated or purified compounds, each of which bind to a metal atom. Generally, the compounds are small in size (e.g, molecular weight of less than about 1 kDa) and peptidic in nature, inasmuch as the compounds comprise amino acids. In some embodiments, the compound comprises a structure of Formula I: M.sub.1-P.sub.1-M.sub.2-P.sub.2 wherein each of P.sub.1 and P.sub.2 is a peptide comprising at least two amino acids, M.sub.1 is a first metal binding moiety comprising a substituted imidazolone ring, M.sub.2 is a second metal binding moiety comprising a substituted oxazolone ring, and wherein M.sub.1 and M.sub.2 bind to a single metal atom. Also provided are related complexes, conjugates, cells which synthesize the compounds of the present disclosures, substantially homogenous cultures thereof, kits and compositions, and methods of making or using the materials of the present disclosures.
Semrau; Jeremy D. (Ann Arbor, MI), Gallagher; Warren (Eau Claire, WI), Yoon; Sukhwan (Ann Arbor, MI), Im; Jeongdae (Ann Arbor, MI), DiSpirito; Alan A. (Ames, IA), Lee; Sung-Woo (Hillsboro, OR), Hartsel; Scott (Eau Claire, WI), McEllistrem; Marcus T. (Eau Claire, WI)
Iowa State University Research Foundation, Inc. (Ames, IA), The Regents of the University of Michigan (Ann Arbor, MI), WiSys Technology Foundation (Madison, WI)
13/ 198,669
August 4, 2011
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with government support under DE-FC2 6-05NT42431 awarded by the Department of Energy. The U.S. government has certain rights in the invention.