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System and process for pulsed multiple reaction monitoring

United States Patent

May 14, 2013
View the Complete Patent at the US Patent & Trademark Office
Pacific Northwest National Laboratory - Visit the Technology Commercialization Program Website
A new pulsed multiple reaction monitoring process and system are disclosed that uses a pulsed ion injection mode for use in conjunction with triple-quadrupole instruments. The pulsed injection mode approach reduces background ion noise at the detector, increases amplitude of the ion signal, and includes a unity duty cycle that provides a significant sensitivity increase for reliable quantitation of proteins/peptides present at attomole levels in highly complex biological mixtures.
Belov; Mikhail E. (Richland, WA)
Battelle Memorial Institute (Richland, WA)
12/ 871,685
August 30, 2010
STATEMENT REGARDING RIGHTS TO INVENTION MADE UNDER FEDERALLY-SPONSORED RESEARCH AND DEVELOPMENT This invention was made with Government support under Contract DE-AC05-76RLO5640 awarded by the U.S. Department of Energy. The Government has certain rights in the invention.