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Recombinant microorganisms for increased production of organic acids

United States Patent

April 30, 2013
View the Complete Patent at the US Patent & Trademark Office
Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.
Yi; Jian (Charlotte, MI), Kleff; Susanne (Okemos, MI), Guettler; Michael V. (Holt, MI)
Michigan Biotechnology Institute (Lansing, MI)
13/ 328,894
December 16, 2011
STATEMENT REGARDING U.S. GOVERNMENT SUPPORT This invention was made with support from the United States Government under Cooperative Agreement No. DE-FC36-02GO12001 awarded by the Department of Energy. The United States Government has certain rights in this invention.