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Antifungal polypeptides

United States Patent

April 3, 2012
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from microbial fermentation broths. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the invention are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention, or variant or fragment thereof, are also disclosed.
Altier; Daniel J. (Granger, IA), Dahlbacka; Glen (Oakland, CA), Ellanskaya; Irina (Kyiv, UA), Ellanskaya, legal representative; Natalia (Kyiv, UA), Herrmann; Rafael (Wilmington, DE), Hunter-Cevera; Jennie (Elliott City, MD), McCutchen; Billy F. (College Station, TX), Presnail; James K. (Avondale, PA), Rice; Janet A. (Wilmington, DE), Schepers; Eric (Port Deposit, MD), Simmons; Carl R. (Des Moines, IA), Torok; Tamas (Richmond, CA), Yalpani; Nasser (Johnston, IA)
Pioneer Hi-Bred International, Inc. (Johnston, IA), E. I. du Pont de Nemours and Company (Wilmington, DE), The Regents of the University of California (Oakland, CA)
12/ 795,770
June 8, 2010
FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with government support under contract number DE-AC02-05CH11231 awarded by the United States Department of Energy. The government has certain rights in the invention.