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Lactic acid-producing yeast cells having nonfunctional L- or D-lactate:ferricytochrome C oxidoreductase cells

United States Patent

March 20, 2012
View the Complete Patent at the US Patent & Trademark Office
Yeast cells having an exogenous lactate dehydrogenase gene ae modified by reducing L- or D-lactate:ferricytochrome c oxidoreductase activity in the cell. This leads to reduced consumption of lactate by the cell and can increase overall lactate yields in a fermentation process. Cells having the reduced L- or D-lactate:ferricytochrome c oxidoreductase activity can be screened for by resistance to organic acids such as lactic or glycolic acid.
Miller; Matthew (Boston, MA), Suominen; Pirkko (Maple Grove, MN), Aristidou; Aristos (Highland Ranch, CO), Hause; Benjamin Matthew (Currie, MN), Van Hoek; Pim (Camarillo, CA), Dundon; Catherine Asleson (Minneapolis, MN)
Cargill Inc. (Wayzata, MN)
12/ 093,757
November 17, 2006
This invention was made with Government support under Cooperative Agreement DE-FC36-03GO13145 awarded by the United States Department of Energy. The Government has certain rights in this invention.