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Method for redesign of microbial production systems

United States Patent

January 31, 2012
View the Complete Patent at the US Patent & Trademark Office
A computer-assisted method for identifying functionalities to add to an organism-specific metabolic network to enable a desired biotransformation in a host includes accessing reactions from a universal database to provide stoichiometric balance, identifying at least one stoichiometrically balanced pathway at least partially based on the reactions and a substrate to minimize a number of non-native functionalities in the production host, and incorporating the at least one stoichiometrically balanced pathway into the host to provide the desired biotransformation. A representation of the metabolic network as modified can be stored.
Maranas; Costas D. (State College, PA), Burgard; Anthony P. (San Diego, CA), Pharkya; Priti (San Diego, CA)
The Penn State Research Foundation (University Park, PA)
12/ 886,649
September 21, 2010
GRANT REFERENCE This invention was made with government support under Grant No. DE-FG03-01ER25499, awarded by the Department of Energy and Grant No. BES0120277, awarded by the National Science Foundation. The Government has certain rights in the invention.