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Method for detecting binding events using micro-X-ray fluorescence spectrometry

United States Patent

December 28, 2010
View the Complete Patent at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
Method for detecting binding events using micro-X-ray fluorescence spectrometry. Receptors are exposed to at least one potential binder and arrayed on a substrate support. Each member of the array is exposed to X-ray radiation. The magnitude of a detectable X-ray fluorescence signal for at least one element can be used to determine whether a binding event between a binder and a receptor has occurred, and can provide information related to the extent of binding between the binder and receptor.
Warner; Benjamin P. (Los Alamos, NM), Havrilla; George J. (Los Alamos, NM), Mann; Grace (Hong Kong, HK)
Los Alamos National Security, LLC (Los Alamos, NM)
09/ 859,701
May 16, 2001
STATEMENT REGARDING FEDERAL RIGHTS This invention was made with government support under Contract No. W-7405-ENG-36 awarded by the U.S. Department of Energy. The government has certain rights in the invention.