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Synthesis of 3'-, or 5'-, or internal methacrylamido-modified oligonucleotides

United States Patent

April 27, 2010
View the Complete Patent at the US Patent & Trademark Office
Argonne National Laboratory - Visit the Technology Development and Commercialization Website
New modifiers were synthesized for incorporation of a methacrylic function in 3'-, 5'- and internal positions of oligonucleotides during solid phase synthesis. A modifier was used for synthesis of 5'-methacrylated oligonucleotides for preparation of microarrays by a co-polymerization method.
Golova; Julia B. (Willowbrook, IL), Chernov; Boris K. (Willowbrook, IL)
UChicago Argonne, LLC (Chicago, IL)
11/ 066,791
February 25, 2005
This invention was partially conceived under Contract No. W-31-109-ENG-38 between the US Department of Energy and The University of Chicago representing Argonne National Laboratory.