Skip to Content
Find More Like This
Return to Search

3-dimensional imaging at nanometer resolutions

United States Patent

March 9, 2010
View the Complete Patent at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
An apparatus and method for enabling precise, 3-dimensional, photoactivation localization microscopy (PALM) using selective, two-photon activation of fluorophores in a single z-slice of a sample in cooperation with time-gated imaging for reducing the background radiation from other image planes to levels suitable for single-molecule detection and spatial location, are described.
Werner; James H. (Los Alamos, NM), Goodwin; Peter M. (Los Alamos, NM), Shreve; Andrew P. (Santa Fe, NM)
Los Alamos National Security, LLC (Los Alamos, NM)
12/ 248,834
October 9, 2008
STATEMENT REGARDING FEDERAL RIGHTS This invention was made with government support under Contract No. DE-AC52-06NA25396 awarded by the U.S. Department of Energy. The government has certain rights in the invention.