Skip to Content
Find More Like This
Return to Search

Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof

United States Patent

December 29, 2009
View the Complete Patent at the US Patent & Trademark Office
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with homoglutamines using these orthogonal pairs.
Anderson; J. Christopher (San Francisco, CA), Wu; Ning (Brookline, MA), Santoro; Stephen (Cambridge, MA), Schultz; Peter G. (La Jolla, CA)
The Scripps Research Institute (La Jolla, CA)
10/ 563,686
July 7, 2004
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT This invention was made with government support under Grant DE-FG0300ER45812 from the Department of Energy. The government may have certain rights to this invention.