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Compositions of orthogonal glutamyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof

United States Patent

May 5, 2009
View the Complete Patent at the US Patent & Trademark Office
Compositions and methods of producing components of protein biosynthetic machinery that include glutamyl orthogonal tRNAs, glutamyl orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of glutamyl tRNAs/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
Anderson; J. Christopher (San Francisco, CA), Schultz; Peter G. (La Jolla, CA), Santoro; Stephen (Cambridge, MA)
The Scripps Research Institute (La Jolla, CA)
10/ 563,656
July 7, 2004
This invention was made with U.S. Government support under Contract No. GM 62159 from the National Institutes of Health and Contract No. DE-FG03-00ER45812 from the Department of Energy. The U.S. Government has certain rights to the invention.