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pH-sensitive methacrylic copolymers and the production thereof

United States Patent

January 9, 2007
View the Complete Patent at the US Patent & Trademark Office
Ames Laboratory - Visit the Iowa State University Research Foundation - Office of Intellectual Property & Technology Transfer Website
The present invention provides novel multi-functional methacrylic copolymers that exhibit cationic pH-sensitive behavior as well as good water solubility under acidic conditions. The copolymers are constructed from tertiary amine methacrylates and poly(ethylene glycol) containing methacrylates. The copolymers are useful as gene vectors, pharmaceutical carriers, and in protein separation applications.
Mallapragada; Surya K. (Ames, IA), Anderson; Brian C. (Lake Bluff, IL), Bloom; Paul D. (Decatur, IL), Sheares Ashby; Valerie V. (Ankeny, IA)
Iowa State University Research Foundation (Ames, IA)
11/ 284,502
November 22, 2005
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT The present inventions were developed using funds provided by the U.S. Department of Energy under contract number W-7405-ENG-82. The U.S. Government has certain rights in and to the present inventions.