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Bioluminescent bioreporter integrated circuit devices and methods for detecting estrogen

United States Patent

August 15, 2006
View the Complete Patent at the US Patent & Trademark Office
Bioluminescent Bioreporter Integrated Circuits
Bioelectronic devices for the detection of estrogen include a collection of eukaryotic cells which harbor a recombinant lux gene from a high temperature microorganism wherein the gene is operably linked with a heterologous promoter gene. A detectable light-emitting lux gene product is expressed in the presence of the estrogen and detected by the device.
Simpson; Michael L. (Knoxville, TN), Paulus; Michael J. (Knoxville, TN), Sayler; Gary S. (Blaine, TN), Applegate; Bruce M. (West Lafayette, IN), Ripp; Steven A. (Knoxville, TN)
UT-Battelle, LLC (Oak Ridge, TN)
11/ 152,138
June 14, 2005
The United States government has rights in the present invention pursuant to grant number DE-FG05-94ER61870 from the Department of Energy and grant number F49620-89-C-0023 from the United States Air Force.