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Derivatized versions of ligase enzymes for constructing DNA sequences

United States Patent

August 15, 2006
View the Complete Patent at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
A method of making very long, double-stranded synthetic poly-nucleotides. A multiplicity of short oligonucleotides is provided. The short oligonucleotides are sequentially hybridized to each other. Enzymatic ligation of the oligonucleotides provides a contiguous piece of PCR-ready DNA of predetermined sequence.
Mariella, Jr.; Raymond P. (Danville, CA), Christian; Allen T. (Tracy, CA), Tucker; James D. (Novi, MN), Dzenitis; John M. (Livermore, CA), Papavasiliou; Alexandros P. (Oakland, CA)
The Regents of the University of California (Oakland, CA)
10/ 718,856
November 21, 2003
The United States Government has rights in this invention pursuant to Contract No. W-7405-ENG-48 between the United States Department of Energy and the University of California for the operation of Lawrence Livermore National Laboratory.