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Hydroxypyridonate and hydroxypyrimidinone chelating agents

United States Patent

January 25, 2005
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides hydroxypyridinone and hydroxypyrimidone chelating agents. Also provides are Gd(III) complexes of these agents, which are useful as contrast enhancing agents for magnetic resonance imaging. The invention also provides methods of preparing the compounds of the invention, as well as methods of using the compounds in magnetic resonance imaging applications.
Raymond; Kenneth N. (Berkeley, CA), Doble; Daniel M. J. (Tigard, OR), Sunderland; Christopher J. (Menlo Park, CA), Thompson; Marlon (Berkeley, CA)
The Regents of the University of California (Oakland, CA)
10/ 194,502
July 12, 2002
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with support awarded by the Department of Energy, Contract No. DE-ACO3-76SF00098, and The Government of the United States of America, NIH Grant No. DK57814 and NIH Grant No. HL69832. The United States Government may have certain rights in this invention.