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Phosphoprotein binding agents and methods of their use

United States Patent

November 16, 2004
View the Complete Patent at the US Patent & Trademark Office
Pacific Northwest National Laboratory - Visit the Technology Commercialization Program Website
The invention provides reagents and methods for characterizing (i.e., identification and/or quantitation) the phosphorylation states of proteins. Proteins may be post-transcriptionally modified such that they contain phosphate groups at either some or all of their serine, threonine, tyrosine, histidine, and/or lysine amino acid residues. In many cases the extent to which a protein is phosphorylated determines it bioactivity, i.e., its ability to effect cell functions such as differentiation, division, and metabolism. Hence, a powerful tool for diagnosing various diseases and for furthering the understanding of protein--protein interactions is provided.
Goshe; Michael B. (Richland, WA), Conrads; Thomas P. (Richland, WA), Veenstra; Timothy D. (West Richland, WA), Panisko; Ellen A. (West Richland, WA)
Battelle Memorial Institute (Richland, WA)
09/ 788,286
February 16, 2001
STATEMENT OF GOVERNMENTAL SUPPORT This invention was made with United States Government support under Contract DE-AC0676RLO1830 awarded by the U.S. Department of Energy. The United States Government has certain rights in the invention.