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Enhancement of NMR and MRI in the presence of hyperpolarized noble gases

United States Patent

November 16, 2004
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.
Pines; Alexander (Berkeley, CA), Budinger; Thomas (Berkeley, CA), Navon; Gil (Ramat Gan, IL), Song; Yi-Qiao (Berkeley, CA), Appelt; Stephan (Waiblingen, DE), Bifone; Angelo (Rome, IT), Taylor; Rebecca (Berkeley, CA), Goodson; Boyd (Berkeley, CA), Seydoux; Roberto (Berkeley, CA), Room; Toomas (Albany, CA), Pietrass; Tanja (Socorro, NM)
The Regents of the University of California (Oakland, CA)
10/ 164,324
June 5, 2002
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with Government support under Contract No. DE-AC03-76SF00098, awarded by the Department of Energy. The Government has certain rights in this invention.