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Microfluidic systems and methods of transport and lysis of cells and analysis of cell lysate

United States Patent

August 31, 2004
View the Complete Patent at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
Microfluidic systems and methods are disclosed which are adapted to transport and lyse cellular components of a test sample for analysis. The disclosed microfluidic systems and methods, which employ an electric field to rupture the cell membrane, cause unusually rapid lysis, thereby minimizing continued cellular activity and resulting in greater accuracy of analysis of cell processes.
Culbertson; Christopher T. (Oak Ridge, TN), Jacobson; Stephen C. (Knoxville, TN), McClain; Maxine A. (Knoxville, TN), Ramsey; J. Michael (Knoxville, TN)
UT-Battelle, LLC (Oak Ridge, TN)
10/ 041,821
October 19, 2001
This invention was made with Government support under contract DE-AC05-00OR22725 awarded by the United States Department of Energy to UT-Battelle, LLC. The Government has certain rights in this invention.