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High throughput microcantilever detector

United States Patent

July 20, 2004
View the Complete Patent at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
In an improved uncoated microcantilever detector, the sample sites are placed on a separate semi-conducting substrate and the microcantilever element detects and measures the changes before and after a chemical interaction or hybridization of the sites by sensing differences of phase angle between an alternating voltage applied to the microcantilever element and vibration of the microcantilever element. In another embodiment of the invention, multiple sample sites are on a sample array wherein an array of microcantilever elements detect and measure the change before and after chemical interactions or hybridizations of the sample sites.
Thundat; Thomas G. (Knoxville, TN), Ferrell; Thomas L. (Knoxville, TN), Hansen; Karolyn M. (Knoxville, TN), Tian; Fang (Oak Ridge, TN)
UT-Battelle, LLC (Oak Ridge, TN)
10/ 462,249
June 16, 2003
The United States Government has rights in this invention pursuant to contract no. DE-AC0500OR22725between the United States Department of Energy and UT-Battelle, LLC.