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Patterned substrates and methods for nerve regeneration

United States Patent

January 13, 2004
View the Complete Patent at the US Patent & Trademark Office
Ames Laboratory - Visit the Iowa State University Research Foundation - Office of Intellectual Property & Technology Transfer Website
Micropatterned substrates and methods for fabrication of artificial nerve regeneration conduits and methods for regenerating nerves are provided. Guidance compounds or cells are seeded in grooves formed on the patterned substrate. The substrates may also be provided with electrodes to provide electrical guidance cues to the regenerating nerve. The micropatterned substrates give physical, chemical, cellular and/or electrical guidance cues to promote nerve regeneration at the cellular level.
Mallapragada; Surya K. (Ames, IA), Heath; Carole (Seattle, WA), Shanks; Howard (Ames, IA), Miller; Cheryl A. (Irvine, CA), Jeftinija; Srdija (Ames, IA)
Iowa State University Research Foundation, Inc. (Ames, IA)
09/ 837,303
April 19, 2001
The United Sates Government has certain rights in this invention pursuant to Grant Numbers W-7405-Eng-82 and BES 997387 from the Department of Energy and the National Science Foundation, respectively.