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Multichannel microscale system for high throughput preparative separation with comprehensive collection and analysis

United States Patent

December 9, 2003
View the Complete Patent at the US Patent & Trademark Office
A modular multiple lane or capillary electrophoresis (chromatography) system that permits automated parallel separation and comprehensive collection of all fractions from samples in all lanes or columns, with the option of further on-line automated sample fraction analysis, is disclosed. Preferably, fractions are collected in a multi-well fraction collection unit, or plate (40). The multi-well collection plate (40) is preferably made of a solvent permeable gel, most preferably a hydrophilic, polymeric gel such as agarose or cross-linked polyacrylamide.
Karger; Barry L. (Newton, MA), Kotler; Lev (Brighton, MA), Foret; Frantisek (Malden, MA), Minarik; Marek (Winthrop, MA), Kleparnik; Karel (Brno, CZ)
Beckman Coulter, Inc. (Fullerton, CA)
09/ 530,118
April 24, 2000
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT Part of the work leading to this invention was carried out with United States Government support provided under a grant from the Department of Energy, Grant No. DE-FG02-90ER60985. Therefore, the U.S. Government has certain rights in this invention.