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Multifunctional recombinant phycobiliprotein-based fluorescent constructs and phycobilisome display

United States Patent

November 18, 2003
View the Complete Patent at the US Patent & Trademark Office
The invention provides multifunctional fusion constructs which are rapidly incorporated into a macromolecular structure such as a phycobilisome such that the fusion proteins are separated from one another and unable to self-associate. The invention provides methods and compositions for displaying a functional polypeptide domain on an oligomeric phycobiliprotein, including fusion proteins comprising a functional displayed domain and a functional phycobiliprotein domain incorporated in a functional oligomeric phycobiliprotein. The fusion proteins provide novel specific labeling reagents.
Glazer; Alexander N. (Berkeley, CA), Cai; Yuping (Indianapolis, IN)
The Regents of the University of California (Oakland, CA)
09/ 469,194
December 21, 1999
The research carried out in the subject application was supported in part by grants from the Department of Energy (Grant No. RDE-FG-91ER61125). The government may have rights in this invention.