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Microbial production of epoxides

United States Patent

June 10, 2003
View the Complete Patent at the US Patent & Trademark Office
Idaho National Laboratory - Visit the Technology Transfer and Commercialization Office Website
A method for microbial production of epoxides and other oxygenated products is disclosed. The method uses a biocatalyst of methanotrophic bacteria cultured in a biphasic medium containing a major amount of a non-aqueous polar solvent. Regeneration of reducing equivalents is carried out by using endogenous hydrogenase activity together with supplied hydrogen gas. This method is especially effective with gaseous substrates and cofactors that result in liquid products.
Clark; Thomas R. (Lakewood, CO), Roberto; Francisco F. (Idaho Falls, ID)
Bechtel BWXT Idaho, LLC (Idaho Falls, ID)
09/ 805,795
March 12, 2001
CONTRACTUAL ORIGIN OF THE INVENTION This invention was made with U.S. Government support under Contract No. DE-AC07-94ID13223, now Contract No. DE-AC07-99ID13727 awarded by the U.S. Department of Energy. The U.S. Government has certain rights in the invention.