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Methods for boron delivery to mammalian tissue

United States Patent

February 11, 2003
View the Complete Patent at the US Patent & Trademark Office
Boron neutron capture therapy can be used to destroy tumors. This treatment modality is enhanced by delivering compounds to the tumor site where the compounds have high concentrations of boron, the boron compounds being encapsulated in the bilayer of a liposome or in the bilayer as well as the internal space of the liposomes. Preferred compounds, include carborane units with multiple boron atoms within the carborane cage structure. Liposomes with increased tumor specificity may also be used.
Hawthorne; M. Frederick (Encino, CA), Feaks; Debra A. (Los Angeles, CA), Shelly; Kenneth J. (Los Angeles, CA)
The Regents of the University of California (Oakland, CA)
09/ 837,147
April 18, 2001
This invention was made with support under Grant Number DE-FG03-95ER 61975 from the Department of Energy. Accordingly, the U.S. Government has certain rights in the invention.