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Transgenic rabbit that expresses a functional human lipoprotein (a)

United States Patent

January 28, 2003
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
A transgenic rabbit which has in its genomic DNA sequences that encode apolipoprotein (a) and apolipoprotein B polypeptides which are capable of combining to produce lipoprotein (a), a process for creating such a rabbit, and the use of the rabbit to identify compounds which are effective in the treatment of human diseases which are associated with, induced and/or exacerbated by Lp(a) expression.
Rouy; Didier (Thiais, FR), Duverger; Nicolas (Paris, FR), Emmanuel; Florence (Aubervilliers, FR), Denefle; Patrice (Saint Maur, FR), Houdebine; Louis-Marie (Buc, FR), Viglietta; Celine (Versailles, FR), Rubin; Edward M. (Berkeley, CA), Hughes; Steven D. (Oakland, CA)
Aventis Pharmaceuticals, Inc. (Bridgewater, NJ)
09/ 227,701
January 8, 1999
This invention was made with government support under grant PPG HL18574, awarded by the National Institutes of Health, and Contract No. DE-AC03-76SF00098 between the U.S. Department of Energy and the University of California. The U.S. government has certain rights in the invention.